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Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling

Wnt/Wg-signalling is critical signalling in all metazoans. Recent studies suggest that IFT-A proteins and Kinesin-2 modulate canonical Wnt/Wg-signalling independently of their ciliary role. Whether they function together in Wnt-signalling and their mechanistic role in the pathway remained unresolved...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Vuong, Linh T., Iomini, Carlo, Balmer, Sophie, Esposito, Davide, Aaronson, Stuart A., Mlodzik, Marek
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294004/
https://ncbi.nlm.nih.gov/pubmed/30546012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07605-z
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