Rational Construction of Compact de Novo-Designed Biliverdin-Binding Proteins

[Image: see text] We report the rational construction of de novo-designed biliverdin-binding proteins by first principles of protein design, informed by energy minimization modeling in Rosetta. The self-assembling tetrahelical bundles bind biliverdin IXa (BV) cofactor autocatalytically in vitro, lik...

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Veröffentlicht in:Biochemistry
Hauptverfasser: Sheehan, Molly M., Magaraci, Michael S., Kuznetsov, Ivan A., Mancini, Joshua A., Kodali, Goutham, Moser, Christopher C., Dutton, P. Leslie, Chow, Brian Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2018
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6293442/
https://ncbi.nlm.nih.gov/pubmed/30468389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01076
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