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Rational Construction of Compact de Novo-Designed Biliverdin-Binding Proteins
[Image: see text] We report the rational construction of de novo-designed biliverdin-binding proteins by first principles of protein design, informed by energy minimization modeling in Rosetta. The self-assembling tetrahelical bundles bind biliverdin IXa (BV) cofactor autocatalytically in vitro, lik...
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| Publicado no: | Biochemistry |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical Society
2018
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6293442/ https://ncbi.nlm.nih.gov/pubmed/30468389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01076 |
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