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Novel metabolic signatures of compound heterozygous Szt2 variants in a case of early‐onset of epileptic encephalopathy

Our study reports the case of a patient with early onset of epileptic encephalopathy harboring compound heterozygous Szt2 variants. We provide the first evidence that these Szt2 variants impair mitochondrial energy metabolism. Our results shed light on their pathogenic molecular mechanism and clinic...

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Detalhes bibliográficos
Publicado no:Clin Case Rep
Main Authors: Uittenbogaard, Martine, Gropman, Andrea, Brantner, Christine A., Chiaramello, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6293145/
https://ncbi.nlm.nih.gov/pubmed/30564332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ccr3.1868
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