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The m.11778 A>G Variant Associated with the Coexistence of Leber’s Hereditary Optic Neuropathy and Multiple Sclerosis-like Illness Dysregulates the Metabolic Interplay between Mitochondrial Oxidative Phosphorylation and Glycolysis
Little is known about the molecular mechanism of the rare coexistence of Leber’s Hereditary Optic Neuropathy (LHON) and multiple sclerosis (MS), also known as the Harding’s syndrome. In this study, we provide novel evidence that the m.11778A>G variant causes a defective metabolic interplay betwee...
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| Publicado no: | Mitochondrion |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6286693/ https://ncbi.nlm.nih.gov/pubmed/29890302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2018.06.001 |
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