The m.11778 A>G Variant Associated with the Coexistence of Leber’s Hereditary Optic Neuropathy and Multiple Sclerosis-like Illness Dysregulates the Metabolic Interplay between Mitochondrial Oxidative Phosphorylation and Glycolysis

Little is known about the molecular mechanism of the rare coexistence of Leber’s Hereditary Optic Neuropathy (LHON) and multiple sclerosis (MS), also known as the Harding’s syndrome. In this study, we provide novel evidence that the m.11778A>G variant causes a defective metabolic interplay betwee...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Mitochondrion
Hlavní autoři: Uittenbogaard, Martine, Brantner, Christine A, ZiShui, Fang, Wong, Lee-Jun, Gropman, Andrea, Chiaramello, Anne
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286693/
https://ncbi.nlm.nih.gov/pubmed/29890302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2018.06.001
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky