A yellow fever–Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice

The recent Zika virus (ZIKV) epidemic in the Americas led to an intense search for therapeutics and vaccines. Here we report the engineering of a chimeric virus vaccine candidate (YF-ZIKprM/E) by replacing the antigenic surface glycoproteins and the capsid anchor of YFV-17D with those of a prototypi...

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Détails bibliographiques
Publié dans:NPJ Vaccines
Auteurs principaux: Kum, Dieudonné B., Mishra, Niraj, Boudewijns, Robbert, Gladwyn-Ng, Ivan, Alfano, Christian, Ma, Ji, Schmid, Michael A., Marques, Rafael E., Schols, Dominique, Kaptein, Suzanne, Nguyen, Laurent, Neyts, Johan, Dallmeier, Kai
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6292895/
https://ncbi.nlm.nih.gov/pubmed/30564463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-018-0092-2
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