Tumor Molecular Testing Guides Anti‐PD‐1 Therapy and Provides Evidence for Pathogenicity of Mismatch Repair Variants

Lynch syndrome is characterized by germline abnormalities in mismatch repair (MMR) genes, leading to predisposition to multiple cancers [1]. A second hit to the unaffected allele is required for tumorigenesis. MMR proteins repair incorrectly paired nucleotides and prevent generation of insertions an...

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Detalhes bibliográficos
Publicado no:Oncologist
Main Authors: Patel, Shyam A., Longacre, Teri A., Ladabaum, Uri, Lebensohn, Alexandra, Lin, Albert Y., Haraldsdottir, Sigurdis
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2018
Assuntos:
Precision Medicine Clinic: Molecular Tumor Board
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6292542/
https://ncbi.nlm.nih.gov/pubmed/30072391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2018-0108
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