Integrin ανβ5 in vitro inhibition limits pro-fibrotic response in cardiac fibroblasts of spontaneously hypertensive rats

BACKGROUND: To date the TGF-β1 activation mediated by integrin ανβ5 during fibrosis is well-known. This process has been shown also in the heart, where cardiac fibroblasts (CF) differentiate into α-smooth muscle actin (α-SMA)-positive myofibroblasts (MyoFB). Here, we studied the effects on CF, isola...

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Publicat a:J Transl Med
Autors principals: Perrucci, Gianluca Lorenzo, Barbagallo, Veronica Antonietta, Corlianò, Maria, Tosi, Delfina, Santoro, Rosaria, Nigro, Patrizia, Poggio, Paolo, Bulfamante, Gaetano, Lombardi, Federico, Pompilio, Giulio
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6292173/
https://ncbi.nlm.nih.gov/pubmed/30541573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1730-1
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