Peripherally Acting μ-Opioid Receptor Antagonists for the Treatment of Opioid-Related Side Effects: Mechanism of Action and Clinical Implications

Opioid receptors are distributed throughout the central and peripheral nervous systems and on many nonneuronal cells. Therefore, opioid administration induces effects beyond analgesia. In the enteric nervous system (ENS), stimulation of µ-opioid receptors triggers several inhibitory responses that c...

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Bibliographic Details
Published in:J Pharm Pract
Main Authors: Streicher, John M., Bilsky, Edward J.
Format: Artigo
Language:Inglês
Published: SAGE Publications 2017
Subjects:
Review Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6291905/
https://ncbi.nlm.nih.gov/pubmed/28946783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0897190017732263
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