The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment

STAT1 has a key role in the regulation of innate and adaptive immunity by inducing transcriptional changes in response to cytokines, such as all types of interferons (IFN). STAT1 exist as two splice isoforms, which differ in regard to the C-terminal transactivation domain (TAD). STAT1β lacks the C-t...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Parrini, Matthias, Meissl, Katrin, Ola, Mojoyinola Joanna, Lederer, Therese, Puga, Ana, Wienerroither, Sebastian, Kovarik, Pavel, Decker, Thomas, Müller, Mathias, Strobl, Birgit
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6291510/
https://ncbi.nlm.nih.gov/pubmed/30574148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02879
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