The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment

STAT1 has a key role in the regulation of innate and adaptive immunity by inducing transcriptional changes in response to cytokines, such as all types of interferons (IFN). STAT1 exist as two splice isoforms, which differ in regard to the C-terminal transactivation domain (TAD). STAT1β lacks the C-t...

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Detalhes bibliográficos
Publicado no:Front Immunol
Principais autores: Parrini, Matthias, Meissl, Katrin, Ola, Mojoyinola Joanna, Lederer, Therese, Puga, Ana, Wienerroither, Sebastian, Kovarik, Pavel, Decker, Thomas, Müller, Mathias, Strobl, Birgit
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6291510/
https://ncbi.nlm.nih.gov/pubmed/30574148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02879
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