Recruitment of Stat1 to chromatin is required for interferon-induced serine phosphorylation of Stat1 transactivation domain

The transcription factor Stat1 plays an essential role in responses to interferons (IFNs). Activation of Stat1 is achieved by phosphorylation on Y701 that is followed by nuclear accumulation. For full transcriptional activity and biological function Stat1 must also be phosphorylated on S727. The mol...

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Bibliografiske detaljer
Main Authors: Sadzak, Iwona, Schiff, Melanie, Gattermeier, Irene, Glinitzer, Reingard, Sauer, Ines, Saalmüller, Armin, Yang, Edward, Schaljo, Barbara, Kovarik, Pavel
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435588/
https://ncbi.nlm.nih.gov/pubmed/18574148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801794105
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