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Decomposing the subclonal structure of tumors with two-way mixture models on copy number aberrations
Multistage tumorigenesis is a dynamic process characterized by the accumulation of mutations. Thus, a tumor mass is composed of genetically divergent cell subclones. With the advancement of next-generation sequencing (NGS), mathematical models have been recently developed to decompose tumor subclona...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6291075/ https://ncbi.nlm.nih.gov/pubmed/30540749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206579 |
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