Both CD4 and CD8 T Cells Mediate Equally Effective In Vivo Tumor Treatment When Engineered with a Highly Avid TCR Targeting Tyrosinase

Tyrosinase, an enzyme involved in melanin synthesis, is expressed in nearly all primary and metastatic melanoma lesions and thus is an attractive target for TCR-based gene therapy using adoptive cell transfer. The TCR α- and β-chain genes from a tumor-infiltrating lymphocyte, which recognized the ty...

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Publicado no:J Immunol
Main Authors: Frankel, Timothy L., Burns, William R., Peng, Peter D., Yu, Zhiya, Chinnasamy, Dhanalakshmi, Wargo, Jennifer A., Zheng, Zhili, Restifo, Nicholas P., Rosenberg, Steven A., Morgan, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290481/
https://ncbi.nlm.nih.gov/pubmed/20427771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000189
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