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Both CD4 and CD8 T Cells Mediate Equally Effective In Vivo Tumor Treatment When Engineered with a Highly Avid TCR Targeting Tyrosinase
Tyrosinase, an enzyme involved in melanin synthesis, is expressed in nearly all primary and metastatic melanoma lesions and thus is an attractive target for TCR-based gene therapy using adoptive cell transfer. The TCR α- and β-chain genes from a tumor-infiltrating lymphocyte, which recognized the ty...
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| Yayımlandı: | J Immunol |
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| Asıl Yazarlar: | , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6290481/ https://ncbi.nlm.nih.gov/pubmed/20427771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000189 |
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