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Genetic insights into the morass of metastatic heterogeneity

Tumour heterogeneity poses a substantial problem for the clinical management of cancer. Somatic evolution of the cancer genome results in genetically distinct subclones in the primary tumour with different biological properties and therapeutic sensitivities. The problem of heterogeneity is compounde...

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Bibliografiske detaljer
Udgivet i:Nat Rev Cancer
Main Authors: Hunter, Kent W., Amin, Ruhul, Deasy, Sarah, Ha, Ngoc-Han, Wakefield, Lalage
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290469/
https://ncbi.nlm.nih.gov/pubmed/29422598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc.2017.126
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