Transcriptional repressor GATA binding 1–mediated repression of SRY-box 2 expression suppresses cancer stem cell functions and tumor initiation

Cancer stem cells (CSCs) have been reported in a variety of cancers. SRY-box 2 (SOX2) is a member of the SOX family of transcription factors and has been shown to play a critical role in maintaining the functions of CSCs and promoting tumor initiation. However, the underlying mechanisms for the tran...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Gong, Xue, Liu, Weiguang, Wu, Lele, Ma, Zhifang, Wang, Yuzhi, Yu, Shiyi, Zhang, Jun, Xie, Hao, Wei, Guanyun, Ma, Fei, Lu, Ling, Chen, Liming
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2018
Sujets:
Gene Regulation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290167/
https://ncbi.nlm.nih.gov/pubmed/30315105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003983
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