Endogenous IL-10 Maintains Immune Tolerance but IL-10 Gene Transfer Exacerbates Autoimmune Cholangitis

The immunomodulatory effect of IL-10 as an immunosuppressive and anti-inflammatory cytokine is well known. Taking advantage of our established mouse model of autoimmune cholangitis using 2-octynoic acid conjugated ovalbumin (2-OA-OVA) induction, we compared liver pathology, immune cell populations a...

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Udgivet i:J Autoimmun
Main Authors: Hsueh, Yu-Hsin, Chen, Hung-Wen, Syu, Bi-Jhen, Lin, Chia-I, Leung, Patrick S.C., Gershwin, M. Eric, Chuang, Ya-Hui
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289859/
https://ncbi.nlm.nih.gov/pubmed/30274824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2018.09.009
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