Deletion of IL-6 in dnTGFβRII Mice Improves Colitis but Exacerbates Autoimmune Cholangitis

The role of IL-6 in autoimmunity attracts attention because of the clinical usage of mAbs to IL-6R, designed to block IL-6 pathways. In autoimmune liver disease, activation of the hepatocyte IL-6/STAT3 pathway is associated with modulating pathology in acute liver failure, liver regeneration and in...

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Hauptverfasser: Zhang, Weici, Tsuda, Masanobu, Yang, Guo-Xiang, Tsuneyama, Koichi, Rong, Guanghua, Ridgway, William M., Ansari, Aftab A., Flavell, Richard A., Coppel, Ross L., Lian, Zhe-Xiong, Gershwin, M. Eric
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936774/
https://ncbi.nlm.nih.gov/pubmed/20578264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23664
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