RNA-mediated dimerization of the human deoxycytidine deaminase APOBEC3H influences enzyme activity and interaction with nucleic acids

Human APOBEC3H is a single-stranded (ss)DNA deoxycytidine deaminase that inhibits replication of retroelements and HIV-1 in CD4+ T cells. When aberrantly expressed in lung or breast tissue APOBEC3H can contribute to cancer mutagenesis. These different activities are carried out by different haplotyp...

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Veröffentlicht in:J Mol Biol
Hauptverfasser: Feng, Yuqing, Wong, Lai, Morse, Michael, Rouzina, Ioulia, Williams, Mark C., Chelico, Linda
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289724/
https://ncbi.nlm.nih.gov/pubmed/30414963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.11.006
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