Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ

Mitochondrial DNA (mtDNA) mutations cause severe maternally inherited syndromes and the accumulation of somatic mtDNA mutations is implicated in aging and common diseases. However, the mechanisms that influence the frequency and pathogenicity of mtDNA mutations are poorly understood. To address this...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Genet
Prif Awduron: Samstag, Colby L., Hoekstra, Jake G., Huang, Chiu-Hui, Chaisson, Mark J., Youle, Richard J., Kennedy, Scott R., Pallanck, Leo J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2018
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289449/
https://ncbi.nlm.nih.gov/pubmed/30452458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007805
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