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Novel in vitro dynamic metabolic system for predicting the human pharmacokinetics of tolbutamide

Liver metabolism is commonly considered the major determinant in drug discovery and development. Many in vitro drug metabolic studies have been developed and applied to understand biotransformation. However, these methods have disadvantages, resulting in inconsistencies between in vivo and in vitro...

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Foilsithe in:Acta Pharmacol Sin
Main Authors: Xue, Cai-fu, Zhang, Zhe, Jin, Yan, Zhu, Bin, Xing, Jun-fen, Ma, Guo, Xiang, Xiao-qiang, Cai, Wei-min
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289352/
https://ncbi.nlm.nih.gov/pubmed/29644999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.201
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