Novel in vitro dynamic metabolic system for predicting the human pharmacokinetics of tolbutamide

Liver metabolism is commonly considered the major determinant in drug discovery and development. Many in vitro drug metabolic studies have been developed and applied to understand biotransformation. However, these methods have disadvantages, resulting in inconsistencies between in vivo and in vitro...

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Udgivet i:Acta Pharmacol Sin
Main Authors: Xue, Cai-fu, Zhang, Zhe, Jin, Yan, Zhu, Bin, Xing, Jun-fen, Ma, Guo, Xiang, Xiao-qiang, Cai, Wei-min
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289352/
https://ncbi.nlm.nih.gov/pubmed/29644999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.201
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