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Novel in vitro dynamic metabolic system for predicting the human pharmacokinetics of tolbutamide
Liver metabolism is commonly considered the major determinant in drug discovery and development. Many in vitro drug metabolic studies have been developed and applied to understand biotransformation. However, these methods have disadvantages, resulting in inconsistencies between in vivo and in vitro...
Guardat en:
| Publicat a: | Acta Pharmacol Sin |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6289352/ https://ncbi.nlm.nih.gov/pubmed/29644999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.201 |
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