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Probing Translocation in Mutants of the Anthrax Channel: Atomically Detailed Simulations with Milestoning

Anthrax toxin consists of a cation channel and two protein factors. Translocation of the anthrax protein factors from endosomal to the cytosolic compartment is a complex process that utilizes the cation channel. An atomically detailed understanding of the function of the anthrax translocation machin...

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Pubblicato in:J Phys Chem B
Autori principali: Ma, Piao, Cardenas, Alfredo E., Chaudhari, Mangesh I., Elber, Ron, Rempe, Susan B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289263/
https://ncbi.nlm.nih.gov/pubmed/30338689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.8b08304
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