Wird geladen...

The Impact of Protonation on Early Translocation of Anthrax Lethal Factor: Kinetics From Molecular Dynamics Simulations and Milestoning Theory

We report atomically detailed molecular dynamics simulations of the permeation of the lethal factor (LF) N-terminal segment through the anthrax channel. The N-terminal chain is unstructured and leads the permeation process for the LF protein. The simulations are conducted in explicit solvent with Mi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Ma, Piao, Cardenas, Alfredo E., Chaudhari, Mangesh I., Elber, Ron, Rempe, Susan B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656527/
https://ncbi.nlm.nih.gov/pubmed/29019235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b07419
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!