Can a Charged Surfactant Unfold an Uncharged Protein?

Does sodium dodecyl sulfate (SDS) denature proteins through electrostatic SDS-protein interactions? We show that a protein completely lacking charged side chains is unfolded by SDS in a manner similar to charged proteins, revealing that formal protein charges are not required for SDS-induced protein...

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Publicat a:Biophys J
Autors principals: Højgaard, Casper, Sørensen, Henrik Vinther, Pedersen, Jan Skov, Winther, Jakob Rahr, Otzen, Daniel Erik
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2018
Matèries:
Biophysical Letter
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289093/
https://ncbi.nlm.nih.gov/pubmed/30447995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.10.022
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