IgG3 regulates tissue-like memory B cells in HIV-infected individuals

Immunoglobulin G3 (IgG3) has an uncertain role in the response to infection with and vaccination against human immunodeficiency virus (HIV). Here we describe a regulatory role for IgG3 in dampening the immune system–activating effects of chronic HIV viremia on B cells. Secreted IgG3 was bound to IgM...

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Publicado en:Nat Immunol
Autores principales: Kardava, Lela, Sohn, Haewon, Youn, Christine, Austin, James W., Wang, Wei, Buckner, Clarisa M., Justement, J. Shawn, Melson, Valerie A., Roth, Gwynne E., Hand, Marissa A., Gittens, Kathleen R., Kwan, Richard W., Sneller, Michael C., Li, Yuxing, Chun, Tae-Wook, Sun, Peter D., Pierce, Susan K., Moir, Susan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289069/
https://ncbi.nlm.nih.gov/pubmed/30104633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0180-5
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