Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors

Chronic immune activation in HIV-infected individuals leads to accumulation of exhausted tissue-like memory B cells. Exhausted lymphocytes display increased expression of multiple inhibitory receptors, which may contribute to the inefficiency of HIV-specific antibody responses. Here, we show that do...

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Detalhes bibliográficos
Main Authors: Kardava, Lela, Moir, Susan, Wang, Wei, Ho, Jason, Buckner, Clarisa M., Posada, Jacqueline G., O’Shea, Marie A., Roby, Gregg, Chen, Jenny, Sohn, Hae Won, Chun, Tae-Wook, Pierce, Susan K., Fauci, Anthony S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127436/
https://ncbi.nlm.nih.gov/pubmed/21633172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45685
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