A Screen Using iPSC-Derived Hepatocytes Reveals NAD(+) as a Potential Treatment for mtDNA Depletion Syndrome

Patients with mtDNA depletion syndrome 3 (MTDPS3) often die as children from liver failure caused by severe reduction in mtDNA content. The identification of treatments has been impeded by an inability to culture and manipulate MTDPS3 primary hepatocytes. Here we generated DGUOK-deficient hepatocyte...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Cell Rep
Main Authors: Jing, Ran, Corbett, James L., Cai, Jun, Beeson, Gyda C., Beeson, Craig C., Chan, Sherine S., Dimmock, David P., Lazcares, Lynn, Geurts, Aron M., Lemasters, John J., Duncan, Stephen A.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289059/
https://ncbi.nlm.nih.gov/pubmed/30404003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.10.036
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares