A Combined Model of Human iPSC‐Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome

Mitochondrial DNA depletion syndrome (MDS) is a group of severe inherited disorders caused by mutations in genes, such as deoxyribonucleoside kinase (DGUOK). A great majority of DGUOK mutant MDS patients develop iron overload progressing to severe liver failure. However, the pathological mechanisms...

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Detalhes bibliográficos
Publicado no:Adv Sci (Weinh)
Main Authors: Guo, Jingyi, Duan, Lifan, He, Xueying, Li, Shengbiao, Wu, Yi, Xiang, Ge, Bao, Feixiang, Yang, Liang, Shi, Hongyan, Gao, Mi, Zheng, Lingjun, Hu, Huili, Liu, Xingguo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8132052/
https://ncbi.nlm.nih.gov/pubmed/34026460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.202004680
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