A Screen Using iPSC-Derived Hepatocytes Reveals NAD(+) as a Potential Treatment for mtDNA Depletion Syndrome

Patients with mtDNA depletion syndrome 3 (MTDPS3) often die as children from liver failure caused by severe reduction in mtDNA content. The identification of treatments has been impeded by an inability to culture and manipulate MTDPS3 primary hepatocytes. Here we generated DGUOK-deficient hepatocyte...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Jing, Ran, Corbett, James L., Cai, Jun, Beeson, Gyda C., Beeson, Craig C., Chan, Sherine S., Dimmock, David P., Lazcares, Lynn, Geurts, Aron M., Lemasters, John J., Duncan, Stephen A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289059/
https://ncbi.nlm.nih.gov/pubmed/30404003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.10.036
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados