A Screen Using iPSC-Derived Hepatocytes Reveals NAD(+) as a Potential Treatment for mtDNA Depletion Syndrome

Patients with mtDNA depletion syndrome 3 (MTDPS3) often die as children from liver failure caused by severe reduction in mtDNA content. The identification of treatments has been impeded by an inability to culture and manipulate MTDPS3 primary hepatocytes. Here we generated DGUOK-deficient hepatocyte...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Jing, Ran, Corbett, James L., Cai, Jun, Beeson, Gyda C., Beeson, Craig C., Chan, Sherine S., Dimmock, David P., Lazcares, Lynn, Geurts, Aron M., Lemasters, John J., Duncan, Stephen A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289059/
https://ncbi.nlm.nih.gov/pubmed/30404003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.10.036
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