5-hydroxymethylcytosine in E-Box motifs ACAT∣GTG and ACAC∣GTG increases DNA-binding of the B-HLH transcription factor TCF4.

We evaluated DNA binding of the B-HLH family members TCF4 and USF1 using protein binding microarrays (PBMs) containing double-stranded DNA probes with cytosine on both strands or 5-methylcytosine (5mC) or 5-hydroxymethylcytosine (5hmC) on one DNA strand and cytosine on the second strand. TCF4 prefer...

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Publicado no:Integr Biol (Camb)
Main Authors: Khund-Sayeed, Syed, He, Ximiao, Holzberg, Timothy, Wang, Jun, Rajagopal, Divya, Upadhyay, Shriyash, Durell, Stewart R., Mukherjee, Sanjit, Weirauch, Matthew T., Rose, Robert, Vinson, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289052/
https://ncbi.nlm.nih.gov/pubmed/27485769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6ib00079g
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