Combined Genetic and Chromosomal Characterization of Wilms Tumors Identifies Chromosome 12 Gain as a Potential New Marker Predicting a Favorable Outcome()()

To identify prognostic factors, array CGH (aCGH) patterns and mutations in WT1 and 9 other genes were analyzed in 128 unilateral Wilms tumors (WTs). Twenty patients had no aCGH aberrations, and 31 had WT1 alterations [silent and WT1 types: relapse-free survival (RFS), 95% and 83%, respectively]. Sev...

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Pubblicato in:Neoplasia
Autori principali: Haruta, Masayuki, Arai, Yasuhito, Okita, Hajime, Tanaka, Yukichi, Takimoto, Tetsuya, Sugino, Ryuichi P., Yamada, Yasuhiro, Kamijo, Takehiko, Oue, Takaharu, Fukuzawa, Masahiro, Koshinaga, Tsugumichi, Kaneko, Yasuhiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press 2018
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Original article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6288985/
https://ncbi.nlm.nih.gov/pubmed/30530054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2018.10.007
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