A high incidence of WT1 abnormality in bilateral Wilms tumours in Japan, and the penetrance rates in children with WT1 germline mutation

BACKGROUND: Bilateral Wilms tumours (BWTs) occur by germline mutation of various predisposing genes; one of which is WT1 whose abnormality was reported in 17–38% of BWTs in Caucasians, whereas no such studies have been conducted in East-Asians. Carriers with WT1 mutations are increasing because of i...

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Enregistré dans:
Détails bibliographiques
Publié dans:Br J Cancer
Auteurs principaux: Kaneko, Y, Okita, H, Haruta, M, Arai, Y, Oue, T, Tanaka, Y, Horie, H, Hinotsu, S, Koshinaga, T, Yoneda, A, Ohtsuka, Y, Taguchi, T, Fukuzawa, M
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
Sujets:
Genetics and Genomics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366886/
https://ncbi.nlm.nih.gov/pubmed/25688735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.13
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