Transcriptional response to Wnt activation regulates the regenerative capacity of the mammalian cochlea

Lack of sensory hair cell (HC) regeneration in mammalian adults is a major contributor to hearing loss. In contrast, the neonatal mouse cochlea retains a transient capacity for regeneration, and forced Wnt activation in neonatal stages promotes supporting cell (SC) proliferation and induction of ect...

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Dades bibliogràfiques
Publicat a:Development
Autors principals: Samarajeewa, Anshula, Lenz, Danielle R., Xie, Lihong, Chiang, Hao, Kirchner, Rory, Mulvaney, Joanna F., Edge, Albert S. B., Dabdoub, Alain
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Ltd 2018
Matèries:
Stem Cells and Regeneration
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6288390/
https://ncbi.nlm.nih.gov/pubmed/30389848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.166579
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