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WDR5 regulates left-right patterning via chromatin-dependent and -independent functions
Congenital heart disease (CHD) is a major cause of infant mortality and morbidity, yet the genetic causes and mechanisms remain opaque. In a patient with CHD and heterotaxy, a disorder of left-right (LR) patterning, a de novo mutation was identified in the chromatin modifier gene WDR5. WDR5 acts as...
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| 出版年: | Development |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Company of Biologists Ltd
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6288385/ https://ncbi.nlm.nih.gov/pubmed/30377171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.159889 |
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