Aplnra/b Sequentially Regulate Organ Left-Right Patterning via Distinct Mechanisms

The G protein-coupled receptor APJ/Aplnr has been widely reported to be involved in heart and vascular development and disease, but whether it contributes to organ left-right patterning is largely unknown. Here, we show that in zebrafish, aplnra/b coordinates organ LR patterning in an apela/apln lig...

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Veröffentlicht in:Int J Biol Sci
Hauptverfasser: Zhu, Chengke, Guo, Zhenghua, Zhang, Yu, Liu, Min, Chen, Bingyu, Cao, Kang, Wu, Yongmei, Yang, Min, Yin, Wenqing, Zhao, Haixia, Tai, Haoran, Ou, Yu, Yu, Xiaoping, Liu, Chi, Li, Shurong, Su, Bingyin, Feng, Yi, Huang, Sizhou
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6567806/
https://ncbi.nlm.nih.gov/pubmed/31223282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.30100
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