Prolyl-4-hydroxylase Α subunit 2 (P4HA2) expression is a predictor of poor outcome in breast ductal carcinoma in situ (DCIS)

BACKGROUND: Extracellular matrix (ECM) plays a crucial role in tumour behaviour. Prolyl-4-hydroxlase-A2 (P4HA2) is a key enzyme in ECM remodelling. This study aims to evaluate the prognostic significance of P4HA2 in breast ductal carcinoma in situ (DCIS). METHODS: P4HA2 expression was assessed immun...

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Pubblicato in:Br J Cancer
Autori principali: Toss, Michael S., Miligy, Islam M., Gorringe, Kylie L., AlKawaz, Abdulbaqi, Khout, Hazem, Ellis, Ian O., Green, Andrew R., Rakha, Emad A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6288166/
https://ncbi.nlm.nih.gov/pubmed/30410060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0337-x
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