Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-4-isopropyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2

[Image: see text] Discoidin-domain receptors 1 and 2 (DDR1 and DDR2) are new potential targets for anti-inflammatory-drug discovery. A series of heterocycloalkynylbenzimides were designed and optimized to coinhibit DDR1 and DDR2. One of the most promising compounds, 5n, tightly bound to DDR1 and DDR...

詳細記述

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書誌詳細
出版年:J Med Chem
主要な著者: Wang, Zhen, Zhang, Yali, Pinkas, Daniel M., Fox, Alice E., Luo, Jinfeng, Huang, Huocong, Cui, Shengyang, Xiang, Qiuping, Xu, Tingting, Xun, Qiuju, Zhu, Dongsheng, Tu, Zhengchao, Ren, Xiaomei, Brekken, Rolf A., Bullock, Alex N., Liang, Guang, Ding, Ke, Lu, Xiaoyun
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2018
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287892/
https://ncbi.nlm.nih.gov/pubmed/30075624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01045
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