A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation

BACKGROUND: The death of epithelial cells in the proximal tubules is thought to be the primary cause of AKI, but epithelial cells that survive kidney injury have a remarkable ability to proliferate. Because proximal tubular epithelial cells play a predominant role in kidney regeneration after damage...

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Détails bibliographiques
Publié dans:J Am Soc Nephrol
Auteurs principaux: Monteiro, Maria B., Ramm, Susanne, Chandrasekaran, Vidya, Boswell, Sarah A., Weber, Elijah J., Lidberg, Kevin A., Kelly, Edward J., Vaidya, Vishal S.
Format: Artigo
Langue:Inglês
Publié: American Society of Nephrology 2018
Sujets:
Basic Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287872/
https://ncbi.nlm.nih.gov/pubmed/30361326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018040392
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