A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation

BACKGROUND: The death of epithelial cells in the proximal tubules is thought to be the primary cause of AKI, but epithelial cells that survive kidney injury have a remarkable ability to proliferate. Because proximal tubular epithelial cells play a predominant role in kidney regeneration after damage...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Monteiro, Maria B., Ramm, Susanne, Chandrasekaran, Vidya, Boswell, Sarah A., Weber, Elijah J., Lidberg, Kevin A., Kelly, Edward J., Vaidya, Vishal S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2018
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287872/
https://ncbi.nlm.nih.gov/pubmed/30361326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018040392
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