Inhibition of the Neuronal Calcium Sensor DREAM Modulates Presenilin-2 Endoproteolysis

Deregulated intracellular Ca(2+) and protein homeostasis underlie synaptic dysfunction and are common features in neurodegenerative diseases. DREAM, also known as calsenilin or KChIP-3, is a multifunctional Ca(2+) binding protein of the neuronal calcium sensor superfamily with specific functions thr...

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Vydáno v:Front Mol Neurosci
Hlavní autoři: Naranjo, Rocío, González, Paz, Lopez-Hurtado, Alejandro, Dopazo, Xosé M., Mellström, Britt, Naranjo, José R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287014/
https://ncbi.nlm.nih.gov/pubmed/30559648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00449
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