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NQO1 Is Regulated by PTEN in Glioblastoma, Mediating Cell Proliferation and Oxidative Stress

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with a dismal prognosis, and the patients carrying EGFR-driven tumors with PTEN mutation do not respond to anti-EGFR therapy. The molecular mechanisms for this resistance remain unknown. Here, we show that PTEN induces the expression o...

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Publicat a:Oxid Med Cell Longev
Autors principals: Luo, Shilin, Lei, Kecheng, Xiang, Daxiong, Ye, Keqiang
Format: Artigo
Idioma:Inglês
Publicat: Hindawi 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286748/
https://ncbi.nlm.nih.gov/pubmed/30595797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/9146528
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