Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma

BACKGROUND: Glioblastoma (GBM) is a universally lethal tumor with frequently overexpressed or mutated epidermal growth factor receptor (EGFR). NADPH quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase Pi 1 (GSTP1) are commonly upregulated in GBM. NQO1 and GSTP1 decrease the formation of re...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Lei, Kecheng, Gu, Xiaoxia, Alvarado, Alvaro G., Du, Yuhong, Luo, Shilin, Ahn, Eun Hee, Kang, Seong Su, Ji, Bing, Liu, Xia, Mao, Hui, Fu, Haian, Kornblum, Harley I., Jin, Lingjing, Li, Hua, Ye, Keqiang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7579906/
https://ncbi.nlm.nih.gov/pubmed/33087132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-020-00979-y
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