Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress

Cyclins A2 and E1 regulate the cell cycle by promoting S phase entry and progression. Here, we identify a hepatocellular carcinoma (HCC) subgroup exhibiting cyclin activation through various mechanisms including hepatitis B virus (HBV) and adeno-associated virus type 2 (AAV2) insertions, enhancer hi...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Bayard, Quentin, Meunier, Léa, Peneau, Camille, Renault, Victor, Shinde, Jayendra, Nault, Jean-Charles, Mami, Iadh, Couchy, Gabrielle, Amaddeo, Giuliana, Tubacher, Emmanuel, Bacq, Delphine, Meyer, Vincent, La Bella, Tiziana, Debaillon-Vesque, Audrey, Bioulac-Sage, Paulette, Seror, Olivier, Blanc, Jean-Frédéric, Calderaro, Julien, Deleuze, Jean-François, Imbeaud, Sandrine, Zucman-Rossi, Jessica, Letouzé, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286353/
https://ncbi.nlm.nih.gov/pubmed/30531861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07552-9
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