Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. High-resolution copy number analysis of 125 tumors of which 24 were subjected to whole-exome sequencing identified 135 homozygous deletions and 994 somatic gene mutations with predicted functional consequences. We identified...

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Bibliografiska uppgifter
Huvudupphovsmän: Guichard, Cécile, Amaddeo, Giuliana, Imbeaud, Sandrine, Ladeiro, Yannick, Pelletier, Laura, Maad, Ichrafe Ben, Calderaro, Julien, Bioulac-Sage, Paulette, Letexier, Mélanie, Degos, Françoise, Clément, Bruno, Balabaud, Charles, Chevet, Eric, Laurent, Alexis, Couchy, Gabrielle, Letouzé, Eric, Calvo, Fabien, Zucman-Rossi, Jessica
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Pub. Co 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819251/
https://ncbi.nlm.nih.gov/pubmed/22561517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2256
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