Synthetic lethal combinations of low-toxicity drugs for breast cancer identified in silico by genetic screens in yeast

In recent years, the concept of synthetic lethality, describing a cellular state where loss of two genes leads to a non-viable phenotype while loss of one gene can be compensated, has emerged as a novel strategy for cancer therapy. Various compounds targeting synthetic lethal pathways are either und...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Marhold, Maximilian, Tomasich, Erwin, Schwarz, Michael, Udovica, Simon, Heinzel, Andreas, Mayer, Paul, Horak, Peter, Perco, Paul, Krainer, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284748/
https://ncbi.nlm.nih.gov/pubmed/30555636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26372
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