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Synthetic lethal combinations of low-toxicity drugs for breast cancer identified in silico by genetic screens in yeast
In recent years, the concept of synthetic lethality, describing a cellular state where loss of two genes leads to a non-viable phenotype while loss of one gene can be compensated, has emerged as a novel strategy for cancer therapy. Various compounds targeting synthetic lethal pathways are either und...
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| Udgivet i: | Oncotarget |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Impact Journals LLC
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6284748/ https://ncbi.nlm.nih.gov/pubmed/30555636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26372 |
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