Rapid, automated characterization of disulfide bond scrambling and IgG2 isoform determination

Human antibodies of the IgG2 subclass exhibit complex inter-chain disulfide bonding patterns that result in three structures, namely A, A/B, and B. In therapeutic applications, the distribution of disulfide isoforms is a critical product quality attribute because each configuration affects higher or...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Resemann, Anja, Liu-Shin, Lily, Tremintin, Guillaume, Malhotra, Arun, Fung, Adam, Wang, Fang, Ratnaswamy, Gayathri, Suckau, Detlev
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284591/
https://ncbi.nlm.nih.gov/pubmed/30277844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1512328
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