Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations

BACKGROUND: Ductal carcinoma in situ (DCIS) is the earliest stage of breast cancer. During DCIS, tumor cells remain inside the mammary duct, growing under a microenvironment characterized by hypoxia, nutrient starvation, and waste product accumulation; this harsh microenvironment promotes genomic in...

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Dettagli Bibliografici
Pubblicato in:EBioMedicine
Autori principali: Ayuso, Jose M., Gillette, Amani, Lugo-Cintrón, Karina, Acevedo-Acevedo, Suehelay, Gomez, Ismael, Morgan, Molly, Heaster, Tiffany, Wisinski, Kari B., Palecek, Sean P., Skala, Melissa C., Beebe, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2018
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Research paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284542/
https://ncbi.nlm.nih.gov/pubmed/30482722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.10.046
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